Diagnosis of brain metastases: an update in 2012

作者：Lechapt Zalcman Emmanuele^*; Karanian Philippe Marie; Rousseau Audrey

来源：Bulletin du Cancer, 2013, 100(1): 29-34.

DOI：10.1684/bdc.2012.1677

• brain metastases
• unknown primary site
• immunohistochemistry
• pathobiology
• targeted therapy

Diagnosis of brain metastases should aim to identify anatomoclinical entities for which a specific treatment is more accurate. Growing numbers of targeted therapies have shown to be effective against specific cancers. Several studies have reported that targeted therapies are capable of reducing brain metastases in melanoma or non small cell lung cancer (NSCLC), sometimes with a high dramatic response. These results have clearly impacted routine neuropathological practice, leading to multidisciplinary strategy management of brain metastases tissues. In accordance with the recommendations of French National Cancer Institute (INCa), the pathologist develops appropriate strategies for molecular and immunohistochemical analysis, in order to provide results as soon as possible.

• 出版日期2013-1