Association of human leukocyte antigen class II allele and haplotypes in chikungunya viral infection in a western Indian population

作者：Thanapati Subrat; Hande Aparna; Das Rumki; Gurav Yogesh; Tripathy Anuradha S^*

来源：Transactions of the Royal Society of Tropical Medicine and Hygiene, 2014, 108(5): 277-282.

DOI：10.1093/trstmh/tru030

• Chikungunya
• HLA class II
• Human leukocyte antigen
• western Indian population

Background: Genes coding for human leukocyte antigen (HLA) class II molecules are polymorphic and have been shown to influence susceptibility to viral diseases.
Methods: One hundred patients with acute chikungunya with and without viral load and 250 chikungunya negative controls from western India were studied for the distribution of HLA class II alleles by PCR with sequence-specific primer (SSP) method.
Results: Frequency of DRB111 allele group (patients vs controls: p0.002, Pc0.036, OR0.21) and haplotype DRB111/DQB103 (patients vs controls: p0.007, OR0.15) were significantly low, while haplotype DRB104/DQB103 (patients vs controls: p0.042, OR1.94) was significantly high in the patient population. HLA DQB104 allele was found only in the patient group with viral load (n17), suggesting possible involvement of the same with chikungunya virus (CHIKV) replication.
Conclusions: Association of HLA-DRB111 and the emergence of DRB111/DQB103 DRB104/DQB103 as resistant and susceptible haplotypes towards CHIKV infection is being reported for the first time. Our results suggest that genetic susceptibility and/or resistance to chikungunya infection may be modulated by HLA class II alleles.

• 出版日期2014-5