Antifungal dibenzofuran bis(bibenzyl)s from the liverwort Asterella angusta

作者：Qu, Jianbo; Xie, Chunfeng; Guo, Huaifang; Yu, Wentao; Lou, Hongxiang^*

来源：Phytochemistry, 2007, 68(13): 1767-1774.

DOI：10.1016/j.phytochem.2007.04.036

• liverworts
• Asterella angusta
• Aytoniaceae
• bis(bibenzyl)s
• antifungal
• asterelin A
• asterelin B
• Candida albicans

Bioactivity-guided separation of an antifungal extract from the liverwort Asterella angusta afforded four bis(bibenzyl)s, asterelin A (1), asterelin B (2), 11-O-demethyl marchantin I (3), and dihydroptychantol A (4), together with six known ones. Their structures were established by extensive spectroscopic analysis (1 D and 2D-NMR, MS), and that of 2 was confirmed by X-ray crystallographic diffraction analysis. Compounds 1 and 2 are the first examples of dibenzofuran bis(bibenzyl)s. The antifungal activity of the isolated bis(bibenzyl)s against the common clinical pathogenic fungus Candida albicans was evaluated using both the thin-layer chromatography bioautographic assay and the broth microdilution method. They showed moderate antifungal activities with minimal inhibitory concentration (MIC) values ranging from 16 mu g/ml to 512 mu g/ml.

• 出版日期2007-7
• 单位晶体材料国家重点实验室; 山东大学