Molecular and immunological effects of hyperthermia on tumor progression and metastasis

作者：Multhoff G^*; Gaipl U

来源：Onkologe, 2010, 16(11): 1043-1050.

DOI：10.1007/s00761-010-1897-4

• Hyperthermia
• Apoptosis
• Necrosis
• Dendritic cells
• Natural killer cells

Hyperthermia treatment in the temperature range 39-43A degrees C can influence the adaptive and natural immune system in addition to the direct toxic effect of temperatures above 41A degrees C on cells. The type of cell destruction (necrosis or apoptosis) plays an important role in whether a pro-inflammatory or anti-inflammatory immune response is triggered by hyperthermia. In addition danger signals, such as high mobility group B1 protein, adenosine-5-triphosphate (ATP) and heat-shock protein, which are released from necrotic tumor cells, can stimulate cells of the natural immune system and therefore assist the anti-tumor response. In this review article the various molecular and immunological mechanisms which are regulated by hyperthermia treatment will be described in detail.

• 出版日期2010-11