Development of a rapid macro-Raman spectroscopy system for nasopharyngeal cancer detection based on surface-enhanced Raman spectroscopy

作者：Lin, Duo; Chen, Guannan^*; Feng, Shangyuan; Pan, Jianji; Lin, Juqiang; Huang, Zufang; Chen, Rong

来源：Applied Physics Letters, 2015, 106(1): 013701.

DOI：10.1063/1.4904992

• SCATTERING
• BLOOD
• DIAGNOSTICS
• DNA

This study aims to evaluate the utility of a home-made surface-enhanced Raman spectroscopy (SERS) system for detection of nasopharyngeal cancer (NPC). A Raman spectral system with a special probe and a millimeter order excitation laser spot size was developed to acquire SERS signals of blood plasma. High quality SERS spectra can be recorded from blood plasma samples belonging to 60 healthy volunteers and 96 NPC patients, and the diagnostic sensitivity and specificity of 95.8% and 91.7%, respectively, can be achieved for classification between normal and cancer blood groups by principal component analysis combined with linear discriminant analysis (PCA-LDA). This exploratory study demonstrates that SERS based on a larger laser spot together with PCA-LDA has the potential for detection of nasopharyngeal cancer, and even for further in vivo cancer detection in the future.

• 出版日期2015-1-5
• 单位福建中医药大学; 福建师范大学; 福建省肿瘤医院