Novel Diubiquitin Probes Expand the Chemical Toolkit to Study DUBs

作者:Kulathu Yogesh*
来源:Cell Chemical Biology, 2016, 23(4): 432-434.
DOI:10.1016/j.chembiol.2016.04.001

摘要

Linkage-specific DUBs employ different mechanisms to recognize and cleave polyubiquitin chains of specific linkage types. In this issue of Cell Chemical Biology, Flierman et al. (2016) develop a new family of novel non-hydrolyzable diubiquitin probes that will be valuable tools to study how DUBs achieve specificity.

  • 出版日期2016-4-21