Metabolic engineering strategies for acetoin and 2,3-butanediol production: advances and prospects

作者：Yang Taowei; Rao Zhiming^*; Zhang Xian; Xu Meijuan; Xu Zhenghong; Yang Shang Tian

来源：Critical Reviews in Biotechnology, 2017, 37(8): 990-1005.

DOI：10.1080/07388551.2017.1299680

• Strain improvement
• 2,3-butanediol dehydrogenase
• regulation mechanism
• biotechnological production
• cofactor engineering
• low-cost substrate
• gene knockout
• construction

Acetoin and 2,3-butanediol (2,3-BD) have a large number of industrial applications. The production of acetoin and 2,3-BD has traditionally relied on oil supplies. Microbial production of acetoin and 2,3-BD will alleviate the dependence on oil. Acetoin and 2,3-BD are neighboring metabolites in the 2,3-BD metabolic pathway of bacteria. This review summarizes metabolic engineering strategies for improvement of microbial acetoin and 2,3-BD production. We also propose enhancements to current acetoin and 2,3-BD production strategies, by offering a metabolic engineering approach that is guided by systems biology and synthetic biology.

• 出版日期2017
• 单位江南大学