Arginine methylation of hnRNP K enhances p53 transcriptional activity

作者：Chen, Yibin; Zhou, Xinyuan; Liu, Na; Wang, Chaochen; Zhang, Liang; Mo, Wei; Hu, Gengxi^*

来源：FEBS LETTERS, 2008, 582(12): 1761-1765.

DOI：10.1016/j.febslet.2008.04.051

• hnRNP K
• UV radiation
• arginine methylation
• p53
• transcriptional regulation

Previous studies have illustrated that hnRNP K, which could be methylated at arginine residues, plays a key role in coordinating transcriptional responses to DNA damage as a cofactor for p53. In this study, we observed that hnRNP K was markedly arginine methylated in response to UV radiation. Furthermore, arginine methylation of hnRNP K enhanced its affinity with p53. Inhibition of methylation in hnRNP K attenuated the recruitment of p53 to p21 promoter, and reduced p53 transcriptional activity. These data suggested that arginine methylation of hnRNP K is a key element for p53 transcriptional activity.

• 出版日期2008-5-28
• 单位分子生物学国家重点实验室; 中国科学技术大学; 中国科学院上海生命科学研究院