Diabetes Mellitus and Alzheimer's Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models

作者：Jia, Jin-Jing; Zeng, Xian-Si^*; Song, Xin-Qiang; Zhang, Peng-peng; Chen, Lei^*

来源：Frontiers in Pharmacology, 2017, 8: 834.

DOI：10.3389/fphar.2017.00834

• diabetes
• Alzheimer's disease
• streptozotocin
• epigallocatechin-3-gallate
• protection

Diabetes mellitus is considered as a risk factor of Alzheimer's disease (AD), the front runner of neurodegenerative disorders. Streptozotocin (STZ) is a toxin for pancreatic beta-cell, which can construct a model of insulin deficient diabetes through intraperitoneal or intravenous injection. A model generated by intracerebroventricular STZ (icv-STZ) also shows numerous aspects of sporadic AD. The protective roles of tea polyphenols epigallocatechin-3-gallate (EGCG) on both two diseases were researched by some scientists. This review highlights the link between diabetes and AD and recent studies on STZ injection-induced models, and also discusses the protection of EGCG to clarify its treatment in STZ-induced diabetes and AD.

• 出版日期2017-11-16
• 单位信阳师范学院