Anti-asthmatic effect of marine red alga (Laurencia undulata) polyphenolic extracts in a murine model of asthma

作者：Jung Won Kyo; Choi Inhak; Oh Sangtaek; Park Sae Gwang; Seo Su Kil; Lee Soo Woong; Lee Dae Sung; Heo Soo Jin; Jeon You Jin; Je Jae Young; Ahn Chang Bum; Kim Jin Soo; Oh Kwang Soo; Kim Young Mog; Moon Chisook; Choi Il Whan

来源：Food and Chemical Toxicology, 2009, 47(2): 293-297.

DOI：10.1016/j.fct.2008.11.012

• Red alga
• Laurencia undulata
• Asthma
• Cytokines
• Airway hyperresponsiveness

The aim of the present work is focused on protective effects of an edible red alga, Laurencia undulata ethanolic (EtOH) extracts (LU) containing a large amount of polyphenols against OVA-induced murine allergic airway reactions using in vivo histological and cytokine assay. Mice sensitized and challenged with ovalbumin (OVA) showed typical asthmatic reactions as follows: an increase in the number of eosinophil in bronchoalveolar lavage fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways, and airway luminal narrowing: the development of airway hyperresponsiveness; the detection of TNF-alpha and Th2 cytokines, such as IL-4 and IL-5 in the bronchoalveolar lavage (BAL) fluid; and detection of allergen-specific IgE in the serum. The successive intraperitoneal administration of LU before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These results suggest that L undulata polyphenolic extracts possess therapeutic potential for combating bronchial asthma associated with allergic diseases.

• 出版日期2009-2