A viable and efficacious catalyst, CeO2/HAp, for green synthesis of novel pyrido[2,3-d]pyrimidine derivatives

作者：Maddila Suresh; Gangu Kranthi Kumar; Maddila Surya Narayana; Jonnalagadda Sreekantha B.^*

来源：Research on Chemical Intermediates, 2018, 44(2): 1397-1409.

DOI：10.1007/s11164-017-3174-2

• Green synthesis
• Multicomponent reactions
• Pyrido-pyrimidines
• Heterogeneous catalyst
• CeO2/HAps
• Recyclability

A facile one-pot green protocol at room temperature has been devised for the synthesis of novel pyrido[2,3-d]-pyrimidine derivatives catalyzed by CeO2-doped hydroxyapatite (CeO2/HAp) with ethanol as solvent. This highly selective method with excellent yields (89-96%) involves a four-component reaction between malononitrile, substituted aldehyde, dimethylbarbituric acid and ammonium acetate. CeO2/HAp was synthesized and characterized by P-XRD, TGA, TEM and SEM analyses. The structures of the target molecules were confirmed by diverse spectroscopic methods (H-1 NMR, N-15 NMR, C-13 NMR, and HRMS). Additional benefits of this eco-friendly approach are the operational simplicity, a stable catalyst with good reusability (at least 6 times), short reaction times (< 45 min) and no need for chromatographic separations. All these features make the proposed method economical and sustainable.
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• 出版日期2018-2