Multiplexed immunoglobulin E sensitization in relation to exhaled nitric oxide in a population sample of children

作者：Yao T C^*; Tsai H J; Tu Y L; Chang S W; Hua M C; Liao S L; Tsai M H; Chiu C Y; Lai S H; Yeh K W; Huang J L

来源：Allergy, 2014, 69(5): 678-682.

DOI：10.1111/all.12378

• Asian
• allergic sensitization
• exhaled nitric oxide
• children
• atopy

This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mites (P%26lt;0.001), animals (P=0.001), cockroaches (P%26lt;0.001), and foods (P=0.042), and furthermore, between FeNO and the number of sensitizations (all P%26lt;0.05) or the sum of specific IgE (all P %26lt;= 0.01) against the aforementioned allergen categories. Specifically, sensitization to the following allergens was significantly related to higher FeNO: Dermatophagoides pteronyssinus, Dermatophagoides farina, Blomia tropicalis, cat, German cockroach, Oriental cockroach, codfish, crab, shrimp, and cheese (all P %26lt;= 0.01). In conclusion, IgE sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is significantly associated with elevated FeNO levels in a dose-dependent fashion in children. Our results provide new evidence that sensitization to certain food allergens may contribute to prompt inflammation in the airways.

• 出版日期2014-5
• 单位长春大学; 西北大学