Agmatine inhibits morphine-induced memory impairment in the mouse step-down inhibitory avoidance task

作者：Lu Wei; Dong Hua Jin; Gong Zheng hua; Su Rui Bin^*; Li Jin

来源：Pharmacology Biochemistry and Behavior, 2010, 97(2): 256-261.

DOI：10.1016/j.pbb.2010.08.007

• Agmatine
• Morphine
• Step-down inhibitory avoidance test
• Memory
• Imidazoline receptor
• Idazoxan

The effect of agmatine on memory formation in morphine-treated mice on the step-down inhibitory avoidance test was examined. Pre-training and pre-test administration of agmatine (5, 10 and 20 mg/kg, s.c.) facilitated memory formation and retrieval while post-training administration of agmatine (5, 10 and 20 mg/ kg, s.c.) had no effect on memory consolidation. Idazoxan (5 mg/kg, i.p.) inhibited the effect of agmatine on memory formation and retrieval. Pre-training administration of morphine (1.25, 2.5 and 5 mg/kg, s.c.) impaired memory formation while post-training and pre-test administration of morphine (1.25, 2.5 and 5 mg/kg, s.c.) had no effect on memory consolidation and retrieval. Pre-training agmatine treatment reversed the impairment of morphine on memory formation. Moreover, pre-test administration of agmatine inhibited morphine-induced amnesia. Pre-training and pre-test idazoxan (5 mg/kg, i.p.) treatment inhibited the effect of agmatine on morphine induced memory impairment. In conclusion, agmatine inhibited morphine-induced memory impairment on the mice step-down inhibitory avoidance test. The mechanism was exerted, at least in part, through activation of imidazoline receptors.

• 出版日期2010-12