科研之友
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摘要
Four novel oxepin-containing pyrimidines, namely oxepinamides D-G (1-4), were isolated from cultures of Aspergillus puniceus F02Z-1744. The structures of 1-4 were elucidated by analyzing their spectroscopic data generated by 1D and 2D NMR and MS methods. The configurations of 1 and 2 were established based on single-crystal X-ray crystallographic analysis. All four compounds 1-4 showed transcriptional activation on Liver X Receptor alpha (LXR alpha) with EC(50) values of 10.6, 12.8, 13.6, and 12.1 mu M, respectively.
- 出版日期2011-2
- 单位河北医科大学
