Novel chemoselective F-18-radiolabeling of thiol-containing biomolecules under mild aqueous conditions

作者：Chiotellis Aristeidis; Sladojevich Filippo; Mu Linjing; Herde Adrienne Mueller; Valverde Ibai E; Tolmachev Vladimir; Schibli Roger; Ametamey Simon M; Mindt Thomas L^*

来源：Chemical Communications, 2016, 52(36): 6083-6086.

DOI：10.1039/c6cc01982j

We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective F-18-labeling of thiol-containing (bio) molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clear advantages for imaging probe development.

• 出版日期2016