Assessment of the Tracer Delay Effect in Whole-Brain Computed Tomography Perfusion: Results in Patients Without Known Neuroanatomic Abnormalities

作者：Hanson Eric H^*; Roach Cayce J; Day Kirtly J; Peters Keith R; Bradley William G Jr; Ghosh Kaushik; Patton Phillip W; McMurray Robert C; Orrison William W Jr

来源：Journal of Computer Assisted Tomography, 2013, 37(2): 212-221.

DOI：10.1097/RCT.0b013e31828004bb

• brain CT perfusion
• computed tomography
• singular value decomposition deconvolution algorithm
• tracer delay-insensitive SVD

Objective: Whole-brain computed tomography perfusion (CTP) data sets generated by tracer delay-insensitive singular value decomposition plus (SVD+) and standard singular value decomposition (sSVD) deconvolution algorithms were evaluated to quantify relatedness and discrepancies in CTP results. %26lt;br%26gt;Methods: Twenty females with symmetrical hemispheric CTP maps indicative of brain tissue without apparent abnormalities were studied. Tissue-specific CTP values were analyzed. %26lt;br%26gt;Results: Standard SVD values were higher than SVD+ for cerebral blood flow. Other CTP values had minimal differences across brain regions. All simple linear regression models were statistically significant (P %26lt; 0.05) except for cerebral blood flow in white matter (P = 0.06). Cerebral blood volume had a good model fit, and mean transit time, a poor fit. %26lt;br%26gt;Conclusions: Corresponding fitted CTP values for sSVD and SVD+ based on regression equations for brain-tissue types are presented. Additional research is required to compare SVD+ and sSVD in disease states when significant hemodynamic brain alterations are present.

• 出版日期2013-4