Glaucoma therapy and ocular surface disease: current literature and recommendations

作者：Anwar Zane; Wellik Sarah R^*; Galor Anat

来源：Current Opinion in Ophthalmology, 2013, 24(2): 136-143.

DOI：10.1097/ICU.0b013e32835c8aba

• benzalkonium chloride
• glaucoma
• ocular surface disease
• preservatives
• recommendations

Purpose of review %26lt;br%26gt;To provide an update on clinical and experimental literature for ocular surface effects of glaucoma therapy and to provide practical guidelines for ophthalmologists treating glaucoma patients with ocular surface disease (OSD). %26lt;br%26gt;Recent findings %26lt;br%26gt;Preservatives, notably benzalkonium chloride (BAK), continue to contribute to OSD and demonstrate a variety of toxic ocular effects both in-vitro, and in animal/human studies. Recent literature frequently compares BAK with Polyquad, SofZia, and preservative-free therapies. Some clinical benefit has been demonstrated with newer BAK-free alternatives. %26lt;br%26gt;Summary %26lt;br%26gt;BAK-free and preservative-free therapies are becoming available but are not always a feasible alternative. It is important to recognize different clinical manifestations of allergy and chronic inflammation and to discuss options for patients experiencing OSD.

• 出版日期2013-3