Advances in the approach to the patient with food allergy

作者：Scurlock Amy M; Jones Stacie M^*

来源：Journal of Allergy and Clinical Immunology, 2018, 141(6): 2002-2014.

DOI：10.1016/j.jaci.2017.12.1008

• Food allergy
• diagnosis
• management
• prevalence
• specific IgE
• prevention
• IgE-mediated food allergy
• oral food challenge
• early intervention
• primary prevention
• evidence-based guidelines
• oral immunotherapy
• sublingual immunotherapy
• epicutaneous immunotherapy

Advances in food allergy diagnosis, management, prevention, and therapeutic interventions have been significant over the past 2 decades. Evidence-based national and international guidelines have streamlined food allergy diagnosis and management, whereas paradigm-shifting work in primary prevention of peanut allergy has resulted in significant modifications in the approach to early food introduction in infants and toddlers. Innovative investigation of food allergy epidemiology, systems biology, effect, and management has provided important insights. Although active therapeutic approaches to food allergy remain experimental, progress toward licensed therapies has been substantial. Mechanistic understanding of the immunologic processes underlying food allergy and immunotherapywill inform the future design of therapeutic approaches targeting the food-induced allergic response. Global strategies to mitigate the substantial medical, economic, and psychosocial burden of food allergy in affected subjects and families will require engagement of stakeholders across multiple sectors in research, health care, public health, government, educational institutions, and industry. However, the relationship between the well-informed allergy care provider and the patient and family remains fundamental for optimizing the care of the patient with food allergy.

• 出版日期2018-6