First total synthesis of the macrophage derived anti-inflammatory and pro-resolving lipid mediator Maresin 2

作者：Rodriguez Ana R; Spur Bernd W^*

来源：Tetrahedron Letters, 2015, 56(1): 256-259.

DOI：10.1016/j.tetlet.2014.11.082

• Maresin 2 (MaR2)
• Total synthesis
• Inflammation resolution
• Wittig reaction
• Chiral pool
• Dess Martin oxidation

The first total synthesis of the potent anti-inflammatory lipid mediator Maresin 2 derived from docosahexaenoic acid, has been achieved. The chiral hydroxy-groups at C13 and C14 were obtained via a chiral pool strategy from 3,4-O-isopropylidene-2-deoxy-D-ribose. Wittig reactions and acetonide cleavage followed by mild ester hydrolysis afforded Maresin 2.

• 出版日期2015-1-1