A pilot trial of body weight reduction for nonalcoholic fatty liver disease with a home-based lifestyle modification intervention delivered in collaboration with interdisciplinary medical staff

作者：Oza Noriko; Eguchi Yuichiro^*; Mizuta Toshihiko; Ishibashi Eriko; Kitajima Yoichiro; Horie Hiroko; Ushirogawa Michiko; Tsuzura Takeko; Nakashita Shunya; Takahashi Hirokazu; Kawaguchi Yasunori; Oda Yasutomo; Iwakiri Ryuichi; Ozaki Iwata; Eguchi Takahisa; Ono Naofumi; Fujimoto Kazuma

来源：Journal of Gastroenterology, 2009, 44(12): 1203-1208.

DOI：10.1007/s00535-009-0115-x

• CT scan
• Visceral fat
• Metabolic syndrome
• Daily weight pattern
• Dropped out

Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of the metabolic syndrome. The aim of this study was to evaluate a 6-month home-based lifestyle modification intervention delivered in collaboration with physicians, hygienists, registered dietitians, and nurses.
Outpatients with NAFLD diagnosed by abdominal ultrasonography were eligible for this study. Abdominal computed tomography (CT) scan evaluated liver fat deposition by the liver-spleen ratio (L/S ratio) and visceral fat accumulation as the visceral fat area (VFA; cm(2)). During the 6-month home-based lifestyle modification intervention, each patient was examined by physicians, nurses, hygienists, and registered dietitians, who provided individualized advice to the patients. Patients recorded their daily weight for self-control of weight with recommended diet and exercise regimens.
Sixty-seven NAFLD patients were enrolled in this study and 22 patients (32.8%) completed the 6-month intervention. Nineteen of the 22 patients achieved significant improvements in body weight, body mass index (BMI), waist circumference, VFA, L/S ratio, and systolic blood pressure, with improved laboratory data. Overall, 39 patients withdrew from the intervention. The mean age of the patients who withdrew was 50.0 +/- A 11.0 years, which was significantly younger than that of the patients who were followed up (60.1 +/- A 10.1 years; P < 0.01).
The reduction in body weight achieved by NAFLD patients during the 6-month intervention was associated with improved fat deposition and liver function. This intervention offers a practical approach for treating a large number of NAFLD patients with lifestyle modification therapy.

• 出版日期2009-12