Organocatalytic Michael-Knoevenagel-Hetero-Diels-Alder Reactions: An Efficient Asymmetric One-Pot Strategy to Isochromene Pyrimidinedione Derivatives

作者：Hong Bor Cherng^*; Dange Nitin S; Ding Chun Feng; Liao Ju Hsiou

来源：Organic Letters, 2012, 14(2): 448-451.

DOI：10.1021/ol202877m

Synthesis of isochromene pyrimidinedione derivatives having five stereocenters has been achieved by a one-pot Michael-Knoevenagel condensation-inverse-electron-demand hetero-Diels-Alder reaction of alpha, beta-unsaturated aldehydes, olefinic nitroalkanes, and 1,3-dimethylbarbituric acid via a one-pot strategy with excellent diastereo- and enantioselectivities (up to 99% ee). The structures and absolute configurations of the products were confirmed by X-ray analysis.

• 出版日期2012-1-20