Association of estrogen receptor alpha and interleukin-10 gene polymorphisms with endometriosis in a Chinese population

作者：Xie Jingyan; Wang Shukui^*; He Bangshun; Pan Yuqin; Li Yujuan; Zeng Qingdi; Jiang Huaxin; Chen Jialiang

来源：Fertility and Sterility, 2009, 92(1): 54-60.

DOI：10.1016/j.fertnstert.2008.04.069

• Endometriosis
• estrogen receptor alpha
• interleukin-10
• gene polymorphism

Objective: To determine whether polymorphisms of the estrogen receptor alpha (ER alpha) and interleukin-10 (IL-10) genes are associated with endometriosis in a Chinese population.
Design: Association study.
Setting: University hospital.
Patient(s): Chinese women diagnosed with endometriosis by laparotomy or laparoscopy.
Intervention(s): Determination of polymorphisms of the ERa and IL-10 genes was performed by polymerase chain reaction and restriction fragment length polymorphism analysis in 214 affected women and 160 controls.
Main Outcome Measure(s): Frequency and distribution of PvuII and XbaI polymorphisms of ERa and of BslI, SspI, and RsaI polymorphisms of IL-10.
Result(s): There was no significant difference between the endometriosis patients and the control groups in the genotype frequency of ER alpha-PvuII and promoter of IL-10 gene polymorphisms in the position of -1082. However, the frequency of ER alpha-XbaI and -592 or -819C alleles of IL-10 in the endometriosis group was significantly higher than that of controls, and further analysis showed that the X allele of ER alpha-XbaI was associated with endometriosis.
Conclusion(s): The X allele of ER alpha-XbaI and the -592 or -819 C allele of IL-10 are associated with endometriosis. (Fertil Steril (R) 2009;92:54-60.

• 出版日期2009-7
• 单位南京医科大学