Attractors in Boolean networks: a tutorial

作者：Hopfensitz Martin; Muessel Christoph; Maucher Markus; Kestler Hans A^*

来源：Computational Statistics, 2013, 28(1): 19-36.

DOI：10.1007/s00180-012-0324-2

• Systems biology
• Boolean networks
• Attractors

Boolean networks are a popular class of models for the description of gene-regulatory networks. They model genes as simple binary variables, being either expressed or not expressed. Simulations of Boolean networks can give insights into the dynamics of cellular systems. In particular, stable states and cycles in the networks are thought to correspond to phenotypes. This paper presents approaches to identify attractors in synchronous, asynchronous and probabilistic Boolean networks and gives examples of their usage in the BoolNet R package.

• 出版日期2013-2