Association of osteoglycin and FAM5C with bone turnover markers, bone mineral density, and vertebral fractures in postmenopausal women with type 2 diabetes mellitus

作者：Tanaka Ken ichiro; Kanazawa Ippei^*; Kaji Hiroshi; Sugimoto Toshitsugu

来源：Bone, 2017, 95: 5-10.

DOI：10.1016/j.bone.2016.11.007

• Osteoglycin
• FAM5C
• Vertebral fracture
• Bone
• Diabetes mellitus

Objective: Accumulating evidence suggests a reciprocal relationship between muscle and bone. Previous in vitro studies showed that the muscle-derived factors, osteoglycin (OGN) and family with sequence similarity 5, member C (FAM5C), regulate osteoblastic differentiation. However, there are no reports investigating the association between circulating OGN and FAM5C and bone metabolism in humans.
Design: We conducted a cross-sectional study and investigated the association of serum OGN'and FAM5C levels and muscle mass examined by whole-body dual-energy x-ray absorptiometry with bone mineral density (BMD), bone turnover markers, and the presence of vertebral fractures (VFs) in 156 postmenopausal women with type 2 diabetes mellitus (T2DM).
Results: Multiple regression analysis adjusted for age, duration of T2DM, body mass index, serum creatinine, and log(hemoglobin Alc) showed that log(OGN) was negatively associated with BMD at the femoral neck beta = -0.17, p = 0.014). Serum OGN levels were higher in subjects with VFs than in those without VFs [mean +/- standard deviation (SD): 100.2 +/- 84.7 vs. 74.4 +/- 31.7 pg/ml, p = 0.013]. Moreover, logistic regression analysis adjusted for the confounding factors described above showed that the serum OGN level was positively associated with the presence of VFs (odds ratio = 1.84, 95% confidence interval = 1.03-3.29 per SD increase, p = 0.039). In contrast, neither the serum FAM5C level nor muscle mass indices were associated with bone turnover markers and the presence of VFs.
Conclusions: The present study showed for the first time that higher serum OGN levels were associated with decreased BMD and increased risk of vertebral fractures in postmenopausal women with T2DM.

• 出版日期2017-2