Proteomic analysis in interstitial lung diseases: a review

作者：Rottoli Paola^*; Bargagli Elena; Landi Claudia; Magi Barbara

来源：Current Opinion in Pulmonary Medicine, 2009, 15(5): 470-478.

DOI：10.1097/MCP.0b013e32832ea4f2

• bronchoalveolar lavage
• interstitial lung diseases
• markers
• proteome
• serum

Purpose of review
This article aims to review the most recent proteomic findings in tissue and biological fluids and application of new technologies for the study of interstitial lung diseases.
Recent findings
New insights into lung cell biology as well as novel pathogenetic pathways of different interstitial lung diseases, potential targets of treatment and specific biomarkers discovered by proteomics have been reported. Proteomics has been applied to different kinds of biological fluids and the most promising material for proteomic analysis of interstitial lung disease is currently bronchoalveolar lavage fluid.
Summary
The results from proteomic studies on this field could be useful in clinical practice for diagnosis, disease progression and severity of interstitial lung diseases.

• 出版日期2009-9