Association Between the p73 Exon 2 G4C14-to-A4T14 Polymorphism and Cancer Risk: A Meta-Analysis

作者：Hu, Yi; Jiang, Lan; Zheng, Jian; You, Yonghe; Zhou, Yifeng; Jiao, Shunchang^*

来源：DNA and Cell Biology, 2012, 31(2): 230-237.

DOI：10.1089/dna.2011.1305

• SQUAMOUS-CELL CARCINOMA
• LUNG-CANCER
• P53 ARG72PRO
• OVARIAN-CANCER
• NEVER-SMOKERS
• ORAL-CANCER
• GENE
• POPULATION
• EXPRESSION
• DELTA-NP73

The TP53 homolog p73 is structurally and functionally similar to TP53 and plays an important role in modulating cell-cycle control, apoptosis, and cell growth. G4C14-to-A4T14 is the most commonly studied polymorphism of this gene for its association with risk of cancers, but the results are confusing rather than conclusive. We performed a meta-analysis using 21 eligible studies with a total of 7581 patients and 10,413 controls to summarize the data for an association between the p73 G4C14-to-A4T14 polymorphism and cancer risk. Compared with the common GC/GC genotype, the AT carriers (AT/GC, AT/AT) had a 1.18-fold elevated risk of cancer (95% confidence interval [CI] =1.11-1.25, p < 0.00001) in a dominant genetic model as estimated in a fixed effect model. The effect of the G4C14-to-A4T14 polymorphism was further evaluated through stratification analysis. In four lung cancer studies, the variant genotypes had a significantly increased risk of lung cancer (odds ratio [OR] = 1.16, 95% CI = 1.04-1.28, p = 0.005). Similar phenomena were also found in two squamous cell carcinoma of the head and neck studies (OR = 1.32, 95% CI = 1.12-1.56, p = 0.0010), two oral cancer studies (OR = 1.57, 95% CI = 1.26-1.95, p < 0.0001), and three colorectal cancer studies (OR = 1.23, 95% CI = 1.01-1.50, p = 0.04). Increased risk of cancer associated with G4C14-to-A4T14 variant genotypes was pronounced in Caucasians (OR = 1.21, 95% CI = 1.11-1.31, p < 0.00001), the Japanese population (OR = 1.24, 95% CI = 1.01-1.52, p = 0.04), and the Korean population (OR = 1.27, 95% CI = 1.07 1.52, p = 0.007). Our meta-analysis suggests that the p73 G4C14-to-A4T14 polymorphism genotypes (GC/AT+AT/AT) may be associated with an increased risk of cancer in most cancer types and ethnicities.

• 出版日期2012-2
• 单位中国人民解放军总医院; 苏州大学