A mix of apple pomace polysaccharide improves mitochondrial function and reduces oxidative stress in the liver of high-fat diet-induced obese mice

作者：Chen, Lei; Liu, Lei; Li, Caixia; Hu, ChengLi; Su, Fan; Liu, Run; Zeng, Mengqi; Zhao, Daina; Liu, Jiankang; Guo, Yurong^*; Long, Jiangang^*

来源：Molecular Nutrition & Food Research, 2017, 61(3): 1600433.

DOI：10.1002/mnfr.201600433

• Apple pomace polysaccharides
• Hepatic metabolic disorder
• High-fat diet
• Mitochondrial function
• "Qinguan"

Scope: Apple pomace polysaccharides (APP), a free radical scavenger, is one of the major compounds derived from apple pomace. However, whether APP has beneficial effects on metabolic disorders is still unknown.
Methods and results: In the present study, water-soluble APP was isolated from the pomace of the locally abundant "Qinguan" apple and chemically characterized. Then, APP was orally administrated to high-fat diet (HFD)-induced obese mice. We found that APP significantly reduced HFD-induced body weight gain and ameliorated HFD-induced hepatic metabolic disorders and oxidative stress. In a palmitate-loaded HepG2 cell model, APP protected the cells from palmitate-induced insulin resistance and loss of viability by suppressing mitochondrial reactive oxygen species and rescuing mitochondrial respiratory function.
Conclusion: Our work suggests that APP, a promising bioactive food component, successfully improved obesity-associated hepatic metabolic disorder, most likely though the activation of hepatic mitochondrial function and the suppression of mitochondria oxidative stress.

• 出版日期2017-3
• 单位陕西师范大学; 甘肃农业大学; 西安交通大学