A 13-week subchronic oral toxicity study of L-serine in rats

作者：Kaneko, I.^*; Han, L.; Liu, T.; Li, J.; Zhao, Y.; Li, C.; Yi, Y.; Liang, A.; Hayamizu, K.

来源：Food and Chemical Toxicology, 2009, 47(9): 2356-2360.

DOI：10.1016/j.fct.2009.06.030

• Safety
• Subchronic toxicity
• L-Serine
• Rats

A subchronic oral toxicity study was conducted to evaluate the safety Of L-serine in Sprague-Dawley rats. The test article was administered once daily by gavage in male and female rats at dose levels of 0, 500, 1500, and 3000 mg/kg body weight/day for 13 weeks. Daily clinical signs. body weight, and food consumption were not affected by ingestion of the test article. There were no treatment-related adverse effects on urinalysis, hematology, serum biochemistry, organ weights, gross and histopathological examination. It was concluded that the no-observed-effect level (NOEL) for L-serine was 3000 mg/kg bw/day for both genders.

• 出版日期2009-9
• 单位中国中医科学院