Umbilical cord blood transplantation for myeloid malignancies

作者：Brunstein Claudio G^*; Baker K Scott; Wagner John E

来源：Current Opinion in Hematology, 2007, 14(2): 162-169.

DOI：10.1097/MOH.0b013e32802f7da4

• acute myeloid leukemia
• chronic myelogenous leukemia
• myelodysplastic syndrome
• nonmyeloblative transplantation
• umbilical cord blood transplantation

Purpose of review
To review the available data on the outcomes of pediatric and adult patients with acute myeloid leukemia, myelodysplastic syndrome and chronic myelogenous leukemia after umbilical cord blood transplantation.
Recent findings
The literature shows that after umbilical cord blood transplantation the relapse rate, disease-free survival and overall survival of patients with myeloid malignancies is similar to other hematopoietic stem cells sources. Disease status at the time of transplantation is found in several studies to be a very important determinant of long-term outcome. Newer strategies such as double umbilical cord blood transplant and utilization of nonmyeloblative conditioning regimens show promising results.
Summary
Umbilical cord blood is a valuable alternative source of hematopoietic stem cells for transplantation of patients with myeloid malignancies who need an allogeneic transplant, but lack a suitable sibling donor.

• 出版日期2007-3