Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells

作者：Weiler Andrea M; Das Arpita; Akinyosoye Oluwasayo; Cui Sherry; O'Connor Shelby L; Scheef Elizabeth A; Reed Jason S; Panganiban Antonito T; Sacha Jonah B; Rakasz Eva G; Friedrich Thomas C; Maness Nicholas J^*

来源：Journal of Virology, 2016, 90(4): 2119-2126.

DOI：10.1128/JVI.01975-15

Nef-specific CD8(+) T lymphocytes (CD8TL) are associated with control of simian immunodeficiency virus (SIV) despite extensive nef variation between and within animals. Deep viral sequencing of the immunodominant Mamu-B(star)017:01-restricted Nef(165-173)IW9 epitope revealed highly restricted evolution. A common acute escape variant, T170I, unexpectedly and uniquely degraded Nef's major histocompatibility complex class I (MHC-I) downregulatory capacity, rendering the virus more vulnerable to CD8TL targeting other epitopes. These data aid in a mechanistic understanding of Nef functions and suggest means of immunity-mediated control of lentivirus replication.

• 出版日期2016-2