Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance

作者：Johnston E; Winters MA; Rhee SY; Merigan TC; Schiffer CA; Shafer RW^*

来源：Antimicrobial Agents and Chemotherapy, 2004, 48(12): 4864-4868.

DOI：10.1128/AAC.48.12.4864-4868.2004

We observed a previously uncharacterized mutation in the protease substrate cleft, L23I, in 31 of 4,303 persons undergoing human immunodeficiency virus type 1 genotypic resistance testing. In combination with V82I, L23I was associated with a sevenfold reduction in nelfinavir susceptibility and a decrease in replication capacity. In combination with other drug resistance mutations, L23I was associated with multidrug resistance and a compensatory increase in replication capacity.

• 出版日期2004-12