Acute renal insufficiency during telavancin therapy in clinical practice

作者：Marcos Luis A^*; Camins Bernard C; Ritchie David J; Casabar Ed; Warren David K

来源：Journal of Antimicrobial Chemotherapy, 2012, 67(3): 723-726.

DOI：10.1093/jac/dkr518

• methicillin-resistant Staphylococcus aureus
• vancomycin-intermediate S
• aureus
• nephrotoxicity
• daptomycin-non-susceptible S
• aureus

To describe the tolerance to long-term telavancin therapy among inpatients as it relates to nephrotoxicity.
Retrospective cohort study of adult patients who received telavancin at the Barnes-Jewish Hospital from 1 September 2009 to 1 December 2010. Patients who received less than three doses of telavancin, were on haemodialysis prior to telavancin administration or died within 48 h of initial telavancin administration were excluded.
Twenty-one patients received telavancin and met the inclusion criteria. Seven of 21 patients (33) developed acute renal insufficiency during therapy. Patients who developed acute renal insufficiency had a mean glomerular filtration rate reduction of 56 mL/min/1.73 m(2). In the univariate analysis, high body mass index (P0.025), use of intravenous contrast dye (P0.017) and prior serum vancomycin trough levels 20 mg/L (P0.017) were associated with developing acute renal insufficiency. Two patients required haemodialysis; two had persistent renal insufficiency.
Supratherapeutic vancomycin trough levels, high body mass index and receipt of intravenous contrast dye prior to telavancin therapy were associated with acute renal insufficiency.

• 出版日期2012-3