A New [2+2+1] Heterocyclization for the Synthesis of 2,3,5-Trisubstituted Thiophenes under Microwave Irradiation

作者：Xu, Hai-Wei; Ma, Guan-Hua; Jiang, Bo^*; Tu, Shu-Jiang

来源：Synthesis (Germany), 2013, 45(24): 3392-3398.

DOI：10.1055/s-0033-1339917

• heterocyclization
• substituted thiophene
• three-component reactions
• -thiocyanato ketone
• 3-(2-aryl-2-oxoethylidene)-2-oxindole

A new three-component strategy for the efficient synthesis of 2,3,5-trisubstituted thiophene derivatives through a [2+2+1] heterocyclization between 3-(2-aryl-2-oxoethylidene)-2-oxindoles and -thiocyanato ketones under microwave irradiation is described. The bond-forming efficiency, accessibility, and generality of this synthesis make it highly valuable to assemble thiophene scaffolds.

• 出版日期2013-12-17