Association Between Jr-Point Elevation and Death From Coronary Artery Disease-15-Year Follow-up of the NIPPON DATA90

作者：Hisamatsu Takashi^*; Ohkubo Takayoshi; Miura Katsuyuki; Yamamoto Takashi; Fujiyoshi Akira; Miyagawa Naoko; Kadota Aya; Takashima Naoyuki; Nagasawa Shin ya; Kita Yoshikuni; Murakami Yoshitaka; Okayama Akira; Horie Minoru; Okamura Tomonori; Ueshima Hirotsugu

来源：Circulation Journal, 2013, 77(5): 1260-1266.

DOI：10.1253/circj.CJ-12-1273

• Cardiovascular diseases
• Coronary artery disease
• Electrocardiography
• Epidemiology
• J-point

Background: An early repolarization pattern, characterized by an elevation of the QRS-ST junction (J-point) on 12-lead electrocardiography (ECG) is associated with cardiac and sudden death. However, little is known about the prognostic significance of J-point elevation for various disease-specific cardiovascular outcomes, including coronary artery disease (CAD).
Methods and Results: To investigate the association between the presence of J-point elevation >= 0.1 mV and various disease-specific cardiovascular outcomes, we conducted a 15-year prospective study in a representative general Japanese population of 7,630 individuals (41% men, mean age 52.4 years) who participated in the National Survey of Circulatory Disorders. Cox models were used to estimate the hazard ratios (HRs) adjusted for possible confounding factors. J-point elevation was present in 264 individuals (3.5%) and was associated with an increased risk of cardiac death (adjusted HR, 2.54; 95% confidence interval [Cl] 1.40-4.58; P=0.002) and death from CAD (adjusted HR, 4.66; 95% Cl 2.30-9.46; P<0.001). In a subgroup analysis by age, the association between J-point elevation and cardiovascular outcomes was more remarkable in middle-aged (<60 years) than in older individuals (>= 60 years) (all P for interaction <0.05).
Conclusions: J-point elevation on standard 12-lead ECG was an independent predictor of cardiac death and death from CAD in a representative sample of the general Japanese population, particularly among the middle-aged. (Circ J 2013; 77: 1260-1266)

• 出版日期2013-5