Age-relevant renal effects of cadmium exposure through consumption of home-harvested rice in female Japanese farmers

作者：Horiguchi Hyogo^*; Oguma Etsuko; Sasaki Satoshi; Okubo Hitomi; Murakami Kentaro; Miyamoto Kayoko; Hosoi Yoko; Murata Katsuyuki; Kayama Fujio

来源：Environment International, 2013, 56: 1-9.

DOI：10.1016/j.envint.2013.03.001

• Cadmium
• Renal effect
• Age
• Rice
• Farmer

There are cadmium-polluted areas in Japan, where farmers may be at risk of renal dysfunction due to cadmium exposure through consumption of home-harvested rice. The aims of this study were to investigate levels of cadmium exposure and accumulation and their renal effects in female farmers residing in cadmium-polluted areas, and to consider the relevance of age to the effects of cadmium. We conducted a cross-sectional study of 1200 women (40-79 years old) without symptomatic disorders in two cadmium-polluted areas and one unpolluted area as a control. Rice, blood, and urine samples were collected to measure the cadmium levels, together with urinary levels of alpha(1)-microglobulin and beta(2)-microglobulin for renal tubular function. Cadmium levels in rice were significantly higher in the polluted areas than control area. Blood and urinary cadmium levels, along with urinary protein levels, were also significantly higher in the polluted areas, especially among the elder subjects. There was one case of cadmium nephropathy in the polluted areas. Age- and urinary cadmium-specific analysis for all the subjects showed a mild linear dose-response relationship between urinary cadmium and proteins in the younger women, and a steep progress of renal dysfunction over the threshold of urinary cadmium (10 mu g/g creatinine) in the older women. In conclusion, the aged women in the polluted areas showed high accumulation of cadmium and deterioration of renal function through consumption of rice. Also, the aging process itself appeared to contribute to the different renal effects of cadmium observed in the elderly population.

• 出版日期2013-6