Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation

作者：Hosoki Koa; Itazawa Toshiko; Boldogh Istvan; Sur Sanjiv^*

来源：Current Opinion in Allergy and Clinical Immunology, 2016, 16(1): 45-50.

DOI：10.1097/ACI.0000000000000231

• cat dander
• myeloid differentiation protein-2
• neutrophils
• pollens
• toll-like receptor 4

Purpose of reviewTo discuss the presence and role of neutrophils in asthma and allergic diseases, and outline the importance of pollen and cat dander-induced innate neutrophil recruitment in induction of allergic sensitization and allergic inflammation.Recent findingsUncontrolled asthma is associated with elevated numbers of neutrophils, and levels of neutrophil-attracting chemokine IL-8 and IL-17 in bronchoalveolar lavage fluids. These parameters negatively correlate with lung function. Pollen allergens and cat dander recruit neutrophils to the airways in a toll-like receptor 4, myeloid differentiation protein-2, and chemokine (C-X-C motif) receptor (CXCR) 2-dependent manner. Repeated recruitment of activated neutrophils by these allergens facilitates allergic sensitization and airway inflammation. Inhibition of neutrophil recruitment with CXCR2 inhibitor, disruption of toll-like receptor 4, or small interfering RNA against myeloid differentiation protein-2 also inhibits allergic inflammation. The molecular mechanisms by which innately recruited neutrophils contribute to shifting the airway inflammatory response induced by allergens from neutrophilic to an eosinophilic-allergic is an area of active research.SummaryRecent studies have revealed that neutrophil recruitment is important in the development of allergic sensitization and inflammation. Inhibition of neutrophils recruitment may be a strategy to control allergic inflammation.

• 出版日期2016-2