Aqueous Phase C-H Bond Oxidation Reaction of Arylalkanes Catalyzed by a Water-Soluble Cationic Ru(III) Complex [(pymox-Me-2)(2)RuCl2] BF4-

作者：Yi Chae S^*; Kwon Ki Hyeok; Lee Do W

来源：Organic Letters, 2009, 11(7): 1567-1569.

DOI：10.1021/ol900097y

The cationic complex [(pymox-Me-2)RuCl2]+BF4- was found to be a highly effective catalyst for the C-H bond oxidation reaction of arylalkanes in water. For example, the treatment of ethylbenzene (1.0 mmol) with t-BuOOH (3.0 mmol) and 1.0 mol % of the Ru catalyst in water (3 mL) cleanly produced PhCOCH3 at room temperature. Both a large kinetic isotope effect (k(H)/k(D) = 14) and a relatively large Hammett value (p -1.11) suggest a solvent-caged oxygen rebounding mechanism via a Ru(IV)-oxo intermediate species.

• 出版日期2009-4-2