Antiproliferative activity of the Antrodia camphorata secondary metabolite 4, 7-dimethoxy-5-methylbenzo [d] [1,3] dioxole and analogues

作者：Yeung, Sing Yee; Piggott, Matthew J.^*

来源：Fitoterapia, 2017, 123: 9-12.

DOI：10.1016/j.fitote.2017.08.019

• Antrodia camphorata
• 4,7-dimethoxy-5-methylbenzo[d] [1,3]dioxole anticancer activity
• NCI-60 screen

Both the traditional Chinese medicinal fungus, Antrodia camphorata, and its secondary metabolite, 4,7-dimethoxy-5-methylbenzo[d] [1,3]dioxole, have been reported to possess promising anticancer activity. In this work the natural product and analogues bearing more polar substituents were synthesised and assessed for antiproliferative activity in the NCI-60 screen. Although each compound inhibited the growth of some cell lines at 10 mu M, none had sufficient activity to warrant further investigation.

• 出版日期2017-11