Assessment of the Prognostic Value of the World Health Organization Clinical Staging System for HIV/AIDS in HIV-Infected Children and Adolescents in a Cohort in Belo Horizonte, Brazil

作者：Araujo Cardoso Claudete A; Pinto Jorge A^*; Sanchez Candiani Talitah M; Carvalho Inacio R; Dantas Andre Grossi; Andrade Goulart Eugenio M

来源：Journal of Tropical Pediatrics, 2012, 58(5): 353-359.

DOI：10.1093/tropej/fmr110

• HIV
• children and adolescents
• WHO clinical stages
• disease progression

This study aimed to evaluate the prognostic value of WHO clinical staging system in HIV-infected children and adolescents in Belo Horizonte, Brazil. WHO clinical stages were evaluated for risk of disease progression in 335 patients admitted from 1989 to 2003. In Kaplan-Meier analysis, age, clinical stage, CD4% %26lt; 15% and viral load %26gt; 5 log(10) were statistically significant. In Cox proportional hazards model, the relative risk of disease progression for Stage 4 at admission and in the worst moment were 3.47 [confidence interval (CI) 95% CI = 1.92-6.26] and 2.89 (95% CI = 1.44-5.79). Stages 2 and 3 were neutral as predictors of risk either of disease progression. CD4% %26lt; 15% and viral load %26gt; 5 log(10) remained statistically significant in multivariate analysis. WHO clinical Stage 4 was a good predictor of risk of progression in this cohort. The findings support WHO proposition to start antiretroviral treatment for patients at a more advanced clinical stage.

• 出版日期2012-10