Longer Duration of the Pringle Maneuver Is Associated With Hepatocellular Carcinoma Recurrence Following Curative Resection

作者：Liu, Shuang; Li, Xiaoqiang; Li, Hui; Guo, Lei; Zhang, Bo; Gong, Zijun; Zhang, Jubo^*; Ye, Qinghai^*

来源：Journal of Surgical Oncology, 2016, 114(1): 112-118.

DOI：10.1002/jso.24271

• Pringle maneuver
• hepatocellular carcinoma
• recurrence
• ischemia time

Objectives: To evaluate the effect of Pringle maneuver time on tumor recurrence following liver resection in patients with hepatocellular carcinoma (HCC). @@@ Methods: In this single-center study, we retrospectively evaluated the effect of Pringle maneuver time on HCC recurrence over a 10-year period from 1999 to 2008 using a Cox regression analysis. @@@ Results: This study enrolled a total of 2,368 patients. A Pringle maneuver time of 15 min was associated with HCC recurrence (log likelihood ratio test, P = 0.001). APringle maneuver time less than 15 min was not a significant risk factor for HCCrecurrence (hazard ratio, HR = 0.97, P = 0.708). However, a Pringle maneuver time greater than 15 min was an independent predictor of HCC recurrence (HR = 1.41, P < 0.001). The patients who underwent the Pringle maneuver for over 15 min had lower overall survival (OS) and recurrence-free survival (RFS) than did those who either did not undergo the maneuver or underwent the maneuver for less than 15 min (both P < 0.001). @@@ Conclusions: These results suggest that a longer duration of the Pringle maneuver increases the risk of tumor recurrence in patients with HCC. However, a shorter duration of the Pringle maneuver decreases this risk.

• 出版日期2016-7-1
• 单位复旦大学