Drug transporters of platinum-based anticancer agents and their clinical significance

作者：Burger Herman^*; Loos Walter J; Eechoute Karel; Verweij Jaap; Mathijssen Ron H J; Wiemer Erik A C

来源：Drug Resistance Updates, 2011, 14(1): 22-34.

DOI：10.1016/j.drup.2010.12.002

• Platinum
• Drug transporters
• Solute carriers (SLCs)
• Organic cation transporters (OCTs)
• PK resistance
• Cimetidine
• Metformin

Platinum-based drugs are among the most active anticancer agents and are successfully used in a wide variety of human malignancies. However, acquired and/or intrinsic resistance still represent a major limitation. Lately, in particular mechanisms leading to impaired uptake and/or decreased cellular accumulation of platinum compounds have attracted attention. In this review, we focus on the role of active platinum uptake and efflux systems as determinants of platinum sensitivity and -resistance and their contribution to platinum pharmacokinetics (PK) and pharmacodynamics (PD). First, the three mostly used platinum-based anticancer agents as well as the most promising novel platinum compounds in development are put into clinical perspective. Next, we describe the presently known potential platinum transporters - with special emphasis on organic cation transporters (OCTs) - and discuss their role on clinical outcome (i.e. efficacy and adverse events) of platinum-based chemotherapy. In addition, transporter-mediated tumour resistance, the impact of potential platinum transporter-mediated drug-drug interactions, and the role of drug transporters in the renal elimination of platinum compounds are discussed.

• 出版日期2011-2