科研之友
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摘要
A novel organocatalyst was developed from d-glucosamine and l-proline, which was shown to catalyze the direct aldol reaction of ketones with aldehydes in a highly diastereoselective and enantioselective manner under solvent-free conditions. The presence of 10 mol% catalyst could promote the reaction effectively, affording the desired aldol products in high yields (70-99%) and excellent selectivities (up to >99:1 dr and up to >99% ee).
