A stereoselective synthesis of fully substituted tetrahydrofurans through 1,3-dipolar cycloaddition with cinnamaldehydes: an easy access to chroman derivatives

作者：Qiu, Lin; Guo, Xin; Zhou, Jun; Liu, Shunying^*; Yang, Liping; Wu, Xiang; Hu, Wenhao

来源：RSC Advances, 2013, 3(43): 20065-20070.

DOI：10.1039/c3ra44123g

• 1 ,3-Dipolarcycloaddition
• Chroman derivatives
• Dipolar cycloaddition reaction
• Economic constructions
• Stereoselective synthesis
• Tetra-hydrofuran
• Tetrahydrofurans

An efficient method of synthesizing the fully-substituted tetrahydrofuran through intermolecular dipolar cycloaddition reactions of aryl diazoesters, beta-nitrostyrenes and cinnamaldehydes was developed. A novel cascade 1,3-dipolar cycloaddition/Michael addition reaction provides a rapid and step-economic construction of highly substituted polycyclic chroman frameworks.

• 出版日期2013
• 单位华东师范大学