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摘要
Objective: In a representative sample of US adults, we investigated the associations of nutrient patterns (NP) with bone mineral density (BMD) and fractures. Design: Cross-sectional. Setting: US community-based National Health and Nutrition Examination Survey (NHANES). Subjects: Participants with measured data on dietary intake and BMD from 2005 to 2010 were included. Principal components analysis was used to identify NP. BMD was measured using dual-energy X-ray absorptiometry. ANCOVA, adjusted logistic and linear regression models were employed, accounting for the complex survey design and sample weights. Results: We included a total of 18318 participants, with 47-0% (n 8607) being men. The mean age was 45.8 years with no sex difference. Three NP emerged, explaining 55.9 % of the variance in nutrient consumption. Multivariable-adjusted linear regressions revealed significant inverse associations between the 'highenergy' NP (rich in carbohydrates and sugar, total fat and saturated fat) and total femur, femoral neck, trochanter and intertrochanter BMD (beta coefficient: -0.029, -0.025, -0.034 and -0.021, respectively, all P < 0.001), while there were significant associations between the 'nutrient-dense' NP (rich in vitamins, minerals and fibre) and 'healthy fat' NP (high dietary PUFA and MUFA) and BMD at total femur, femoral neck, trochanter and intertrochanter (all P < 0.001). In adjusted logistic regression models, the odds of hip, wrist or spine fractures did not vary significantly across NP quartiles. Conclusions: Nutrient-dense and healthy fat NP are associated with higher BMD at various bone sites, while the high-energy NP is inversely associated with BMD measures.
- 出版日期2018-9
- 单位中国科学院大学; Saskatoon; 中国科学院遗传与发育生物学研究所
