A new iridoid and effect on the rat aortic vascular smooth muscle cell proliferation of isolated compounds from Buddleja officinalis

作者：Bui Huu Tai; Nguyen Xuan Nhiem; Tran Hong Quang; Nguyen Thi Thanh Ngan; Nguyen Huu Tung; Kim Yohan; Lee Jung Jin; Myung Chang Seon; Nguyen Manh Cuong; Kim Young Ho

来源：Bioorganic & Medicinal Chemistry Letters, 2011, 21(11): 3462-3466.

DOI：10.1016/j.bmcl.2011.03.078

• Methylscutelloside
• Vascular smooth muscles cells
• Platelet derived growth factor
• Buddleja officinalis

A new iridoid, named methylscutelloside (1) together with 19 known compounds belonging to the iridoids (2-4), monoterpenoids (5), flavonoids (6-8), triterpenoids (9-14), and phenylethanoids (15-20) were isolated from the flowers of Buddleja officinalis. Their chemical structures were elucidated on the basis of physicochemical properties, and by spectroscopic methods including 1D, 2D NMR, and MS. All isolated compounds were tested in vitro for their effects on the proliferation of rat aortic vascular smooth muscle cells (VSMCs). Among them, iridoids were the main active components and showed significant inhibitory effects on PDGF-BB-induced proliferation in rat aortic VSMCs.

• 出版日期2011-6-1