Diiodo-Bodipy-Encapsulated Nanoscale Metal Organic Framework for pH-Driven Selective and Mitochondria Targeted Photodynamic Therapy

作者：Guan, Qun; Zhou, Le-Le; Li, Yan-An^*; Dong, Yu-Bin^*

来源：Inorganic Chemistry, 2018, 57(16): 10137-10145.

DOI：10.1021/acs.inorgchem.8b01316

• SINGLET OXYGEN
• NANOPARTICLES
• PHOTOSENSITIZER
• GENERATION
• MOLECULES
• LIGAND
• CELLS
• DYES

We report herein a new ZIF-90-based PDT agent which was synthesized by in situ assembly of imidazole-2-carboxaldehyde (IcaH), Zn(NO3)(2), and heavy atom iodine-attached Bodipy. The obtained 2I-BodipyPhNO2@ZIF-90 (1) host guest photosensitive system featured low cytotoxicity, good biocompatibility, pH-driven selective cancer cell uptake and release, mitochondria targeting, and highly efficient pH-triggered O-1(2) generation. Therefore, it can be used as a high-performing PDT agent to selectively kill tumor cells. In comparison to free 2I-BodipyPhNO(2), 1 exhibits a much higher antitumor efficacy and selectivity, which was confirmed by in vitro cell experiments.

• 出版日期2018-8-20
• 单位山东师范大学