ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE)

作者：Roca Mezquita Carolina; Graniel Sabido Manlio; Moo Puc Rosa E; Leon Deniz Lorena V; Gamboa Leon Rubi; Arjona Ruiz Carely; Tun Garrido Juan; Miron Lopez Gumersindo; Mena Rejon Gonzalo J^*

来源：African Journal of Traditional, Complementary and Alternative Medicines, 2016, 13(4): 162-165.

DOI：10.21010/ajtcam.v13i4.21

• Elaeodendron trichotomum
• antiprotozoal activity
• Celastraceae
• tingenone
• pristimerin
• root bark

Background: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to evaluate the antiprotozoal activity of leaves, stem bark and root bark of Elaeodendron trichotomum, a celastraceus, that is used in Mexico as an anti-infective in febrile-type diseases.
Materials and methods: Dichloromethane and methanol extracts of leaves, bark and roots of Elaeodendron trichotomum were tested against Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, and Trypanosoma cruzi. A quantitative HPLC analysis of pristimerin and tingenone was performed.
Results: The dichloromethane extract of roots was active against E. histolytica, G. lamblia, T. vaginalis, and T. cruzi, at IC50's of 0.80, 0.44, 0.46, and 2.68 mu g/mL, respectively. The HPLC analysis revealed the presence of tingenone (3.84%) and pristimerin (0.14%).
Conclusions: The dichloromethane extract of the roots bark showed significant activity against all screened protozoa.

• 出版日期2016