A Mechanism for Somatic Brain Mosaicism

作者:Weissman Irving L; Gage Fred H*
来源:Cell, 2016, 164(4): 593-595.
DOI:10.1016/j.cell.2016.01.048

摘要

Double-strand break repair is required for neural development, and brain cells contain somatic genomic variations. Now, Wei et al. demonstrate that neural stem and progenitor cells undergo very frequent DNA breaks in a very restricted set of genes involved in neural cell adhesion and synapse function.

  • 出版日期2016-2-11