Musculoskeletal complications following total body irradiation in hematopoietic stem cell transplant patients

作者：Jackson Taylor J.; Mostoufi-Moab Sogol; Hill-Kayser Christine; Balamuth Naomi J.; Arkader Alexandre^*

来源：Pediatric Blood and Cancer, 2018, 65(4): e26905.

DOI：10.1002/pbc.26905

• hematopoietic stem cell transplantation
• late-onset effects
• osteochondroma
• osteonecrosis
• radiation-induced sarcoma
• short stature
• slipped capital femoral epiphysis
• total body irradiation

Total body irradiation (TBI) is commonly used in conditioning regimens for allogeneic hematopoietic stem cell transplantation (HSCT) to treat benign and malignant disease. Though life-saving, these therapies place patients at risk for important side effects, including musculoskeletal complications such as short stature, osteonecrosis, slipped capital femoral epiphysis, and the development of benign and malignant bone tumors. With an increasing number of HSCT survivors, there is a growing need for awareness of the musculoskeletal complications of HSCT and TBI.

• 出版日期2018-4