Urinary phthalate monoesters and endometriosis in infertile Japanese women

作者：Itoh Hiroaki; Iwasaki Motoki^*; Hanaoka Tomoyuki; Sasaki Hiroshi; Tanaka Tadao; Tsugane Shoichiro

来源：Science of the Total Environment, 2009, 408(1): 37-42.

DOI：10.1016/j.scitotenv.2009.09.012

• Epidemiology
• Urine
• Estrogenic
• Phthalate
• Endocrine disrupter

Phthalates may act as an estrogen and are a potential risk factor for estrogen-related diseases such as endometriosis, We assessed the association between phthalate exposure and endometriosis in 166 consecutive women who presented at a university hospital for consultation regarding infertility. The subjects were interviewed and provided a urine specimen prior to a laparoscopic diagnosis of endometriosis. They were then categorized by the severity of endometriosis as controls (stages 0-1) and cases (stages II-IV). Urinary concentrations of the phthalate metabolites monoethyl phthalate. mono-n-butyl phthalate, monobenzyl phthalate, mono (2-ethyl hexyl) phthalate (MEHP), mono (2-ethyl-5-oxohexyl) phthalate, and mono (2-ethyl-5-hydroxyhexyl) phthalate were measured in 57 cases and 80 controls using high-performance liquid chromatography isotope-dilution tandem mass spectrometry. Adjusted odds ratios for endometriosis in relation to dichotomized individual phthalate metabolites (standardized for creatinine) were calculated. No significant association between endometriosis and any urinary creatinine-adjusted phthalate monoester was seen. Adjusted odds ratio (95% confidence interval) for higher dichotomized MEHP by endometriosis was 1.57 (0.74-3.30). No monotonic trend was seen in urinary creatinine-adjusted concentration of phthalate metabolites by endometriosis stage (p = 0.23-0.90). Our results do not support the hypothesis that higher urinary concentrations of phthalate metabolites are associated with the risk of endometriosis in infertile Japanese women.

• 出版日期2009-12-15